Peroxisomal Proliferator Activated Receptors

Peroxisome proliferators (PPs) are a group of structurally unrelated compounds that cause massive proliferation of hepatic peroxisomes, liver hyperplasia, and hepatic malignancies in rodents (reviewed in Lemberger et al., 1996a Schoonjans et al., 1996b). This class of compounds includes many industrial chemicals and herbicides as well as drugs used to treat hypercholesterolemia and other lipid abnormalities. Peroxisomal prolifera-tors potentially exert their short- and medium-term effects...