Activation of trans Geometry

Structure-activity studies often employ inactive compounds such as transplatin [trans-diamminedichloroplatinum(ll), trans-isomer of cisplatin] (Figure 25.3).31 Transplatin-DNA adducts are mainly interstrand cross-links preferentially formed between guanine and complementary cytosine residues32 and a relatively

H3N CI H3N CI

Pt A

Transplatin /rara-[PtCl2(NH,)(thiazolc)] Zram'-fPtCl^NHjXquinoline)]

CH3X /och3 c

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