The bis-chelated tetrahedral Au(l) phosphine complexes described in section 26.5.3 have also been evaluated for anti-microbial activity and shown to have moderate activity but not as good as compared to their Ag(l) analogues.88 Gold(l) complexes containing a P—Au—N core such as Ph3PAu(imidazolate) (16) (Figure 26.6) show selective and significant anti-microbial activity against two Gram-positive bacteria, namely Bacillus subtilis and Staphylococcus aureus, moderate activity against a yeast (Candida albicans) and no activity against the Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa, and
Figure 26.6 Chemical structures of Ph3PAu(imidazolate) (16), Ph3PAu(6-mercapton-icotinicate) (17) and 2-benyzlpyridylgold(III) catecholate (18)
the molds Aspergillis niger and Penicillium citrinum.89 Analogues to Auranofin (6) can also show selective activity against Gram-positive bacteria, e.g. Ph3PAu(6-mercaptonicotinate) (17), Figure 26.6. Nomiya etal. have suggested that the specific profiles of anti-microbial activity of the linear Au(I) complexes can be correlated with ease of ligand substitution, i.e. complexes that were stable to substitution to biologically relevant thiols were not active.90 Gold(III) complexes have also been examined for anti-microbial activity.91 Selectively in activity was determined for some complexes, such as the catecholate complex (18), shown in Figure 26.6, against B. subtilis and P. aeruginosa, i.e. Grampositive and -negative bacteria, respectively.91
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