Non-platinum metal-based drugs may be considered as an independent group of anti-tumor agents, and there is hope that some of them may improve the prognosis of patients suffering from certain cancer diseases.16 Budotitane shows good anti-tumor activity against colon tumor models,18 and titanocene dichloride shows activity against human adenocarcinomas of the stomach and colon, which are insensitive to common cytostatic agents.23
Although budotitane and titanocene dichloride have not shown convincing results in human clinical trials I or II up to now, there is still hope that, by modification of either their chemical configuration or the galenic formulation, there could be a new management of tumors, which so far have not been treatable with chemotherapy.
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