Cyclic Thiourea Derivatives

The rationale behind the development of boronated cyclic thiourea derivatives is that their boron-free analogues have the capacity for becoming incorporated into the polymeric structure of melanin through covalent bonding into melanin precursors, based on the enol form of the thiourea moiety.69 Tjarks and Gabel synthesized carborane-containing cyclic thioureas as well as the first dihydroxyl-

Figure 2.30 Boronated nitroimidazoles
Figure 2.31 Boronated thioureas

boryl-containing thiouracils.70 This compound showed greater tumor persistence than did BPA.70 Substantial synthetic work has been focused on the synthesis of c/oso-carboranylthiouracils.71 Representative structures are depicted in Figure 2.31.

Was this article helpful?

0 0
10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment