Diabetes

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Diabetes was first related to manganese by a report that a diabetic man had reductions in blood glucose in response to doses of 5-10 mg manganese and elevated urinary excretion as determined by doses of 54Mn.58 Also, protracted hypoglycemia following a glucose load was observed in workers with manganese toxicity.59 Yet a clinical trial in which subjects were given varying manganese doses (to 10 mg) showed no influence on blood glucose.10 Nonetheless, several studies have found that insulin mRNA is decreased in manganese-deficient rats, suggesting a role for manganese in its transcription or turnover.10 Another possible association could be the protective role that SOD2 plays in minimizing the oxidative damage from overproduction of ROS in diabetic hyperglycemia. In the three main pathways of pathogenesis of hyperglycemic damage, normalizing levels of SOD2 in bovine aortic endothelial cells prevented the pathogenesis.60 These results suggest that therapy with SOD mimetics warrant further investigation.

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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