Ferrocene in Drug Design

There are many examples in the literature where a phenyl or alkyl group has been replaced by ferrocene as a drug design strategy. However, the anticipated outcome

(increase in activity) has not always been encountered. In some instances, the introduction of ferrocene abolished or markedly reduced activity in the resulting compound. In other cases, activity was more or less retained. There are also instances where an increase in activity or an unexpected change in activity profile was detected. Some of these examples are discussed in the following paragraphs.

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