Introduction

For years, medicinal chemistry was almost exclusively based on organic compounds and natural products. Although the fundamental importance of life dependence on metal ions has been recognized from oldest times,1,2 scarce attention has been given to inorganic substances. However, during the past three decades, transition metal complexes have been isolated and studied as potential cancer chemotherapeutic agents.3 6 Concretely, the success of cis-dichlorodiammine platinum complex (cisplatin) in humans and the remarkable anti-tumour activity of cisplatin-like compounds have clearly provided great impetus for search towards finding more active and selectively cytotoxic inorganic complexes.7 11 Over the years a large number of complexes containing platinum or non-platinum metals have been found to be effective against a variety of experimental tumours.12 18

Much research on anti-tumour compounds has been carried out synthesizing and characterizing new non-platinum metal complexes, where the nature of both the metal and the ligand were varied. It is remarkable that investigations in this area are focused on the use of biologically active complexes formed by essential ions, such as copper.19 Since any essential metal which escapes its normal metabolic pathways can be very toxic to the organism (for example,

Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine Edited by Gielen and Tiekink © 2005 John Wiley & Sons, Ltd

H2KTS CuKTS

(H2KTS: 3-ethoxy-2-oxobutyraldehyde, bTSC; R4 = ethoxyethyl, R1-R3 = H)

H2KTS CuKTS

(H2KTS: 3-ethoxy-2-oxobutyraldehyde, bTSC; R4 = ethoxyethyl, R1-R3 = H)

Figure 12.1 General structures of bis(thiosemicarbazones) (bTSC) and their copper complexes copper in Wilson disease), complexes of such metals may serve as effective cytotoxic agents.2,20 Indeed, it is well known for many years that a large number of bis(thiosemicarbazones) (bTSC) H2KTS and several groups of their copper complexes CuKTS, whose generalized structure is shown in Figure 12.1, show promising anti-tumour activities.21 The anti-cancer action of CuKTS has been clearly demonstrated in in vitro and in vivo experiments.19

In this chapter, the biological properties of recently obtained selected compounds of the most important groups of chemotherapeutic copper complexes will be discussed. Special emphasis would be focused on bTSC-type copper complexes, the most investigated group of biologically active substances.

Was this article helpful?

0 0
10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment