It has been found that various natural and synthetic ether lipids possess a proclivity for and persistence in a variety of spontaneous and chemically induced tumors. This is due, in part, to the absence of the enzyme O-alkylgly-cerol mono-oxidase in their neoplasms. Accordingly, Lemmen and Werner have synthesized the carborane-containing phospholipid shown in Figure 2.29.64 However, the results both from cell culture studies and in tumor-bearing
animals were not particularly encouraging. Since then, very little additional work has appeared in the literature.
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