PalladiumII complexes with Schiff base ligands

Schiff base complexes of Pd(II), derived by the template condensation of 1,10-phenanthroline-2,9-dicarboxaldehyde, 2,3-diamino-1,4-naphthoquinone and 1,2-dibromoethane in ethanol (L) (Figure 21.5), of formula [Pd(L)Br2] • 2H2O,22 together with the corresponding Mn(II) complex were synthesized and tested for anti-bacterial activity, against B. cereus and other G(+) and G(—) strains.22 The complexes were more active than sodium penicillin against B. cereus. The Pd(II) complex showed good activity against G(—) strains.

Azole (thiazolo and triazolo)-2,4-pentanedione (L1 and L2) were condensed with o-phenylenediamine in the presence of NiCl2, CuCl2 and PdCl2, and the resulting trinuclear/polynuclear complexes were characterized and tested against the crop-damaging fungi, such as Alternaria brasicae and Fusarium lycopersici.23 The fungi-toxicities of the compounds were evaluated and the evaluations indicated that all metal complexes had a better anti-fungal activity than their parent ligands, with the more active complex being the Pd(II) complex23 (Figure 21.6).

Figure 21.6

New Pd(II) complexes of biologically active ketimines containing NOH groups of formulae Pd(L)2 and Pd(L)2Cl2 were synthesized, characterized and tested for anti-microbial activity24 together with their ligands (L), i.e. 2-acetyl-furan semicarbazone (HSCZ^, 2-acetylthiophene semicarbazone (HSCZ2), 2-acetylpyridine semicarbazone (HSCZ3) and 2-acetylnaphthalene semicarbazone (HSCZ4). The metal chelates showed greater inhibitory effects than the parent ligands.

Complexes of Pd(II) with Schiff bases derived from the condensation of 2-acetylpyridine and S-methyldithiocarbazate (SMDT), S-benzyldithiocarbazate (SBDT) and thiosemicarbazide (TSCD) of formula [Pd(L)Cl2] were synthesized and tested against E. histolytica (strain HK-9).25 The first two showed greater activity and the third one, activity similar to that of metronidazole of IC50 0.33 mg/mL.

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