One of the most provocative uses of a manganese-containing compound is extending the lifespan. A SOD mimetic, manganese 5,10,15,20-tetrakis-(4-benzoic acid) porphyrin (MnTBAP) (Figure 9.4), was administered by intraperitoneal injection to mice with a SOD2 knockout. Use of this synthetic antioxidant in these transgenic mice increased the survival time by 100%, from 8 to 16 days of age.13 Cardiac pathology and lipid accrual in the liver were reduced but the mice developed neurological disorders at day 12, due to a spongiform encephalopathy. Since the MnTBAP was unable to cross the
blood-brain barrier, the ultrastructural changes in the brain were attributed to age-related oxidative damage that was allowed to proceed with the alleviation of the cardiomyopathy.
Was this article helpful?
Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.