Although the use of metal-based imaging agents has become commonplace in modern hospitals, the development of metal-based therapeutic radiopharma-ceuticals has been somewhat slower with only a limited number of agents in current clinical use for the treatment of cancers. Despite this, it has been predicted that there will be a huge growth in the therapeutic application of metal complexes in the next 10-20 years and biotechnology companies are beginning to place particular focus on medicinal inorganic chemistry. To utilize fully the potential of therapeutic metal complexes, more research is needed into the fundamental chemistry of the radionuclides with bifunctional chelators with the ability to deliver the radiometal selectively to the tumour site. Hopefully, this brief review will serve to summarize the current status of the rapidly developing field and provide some pointers to potentially productive future areas of research.
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