The Din Butyltin Analogue of Carboplatin

The di-n-butyltin analogue of carboplatin (Figure 22.2) was synthesized and screened against MCF-7 and WIDR because this was an early result that was obtained when the panel comprised only these two cell lines.57,58

The diorganotin compound was characterized by ID50 values of 63 and 121 ng/ml, respectively, whereas the ID50 values of cisplatin were 699 and 967 ng/ml.

O NH3

Tin Compounds and Their Therapeutic Potential O

O NH3

Tin Compounds and Their Therapeutic Potential O

Figure 22.2 Carboplatin and the di-n-butyltin analogue of carboplatin

Carboplatin

Di-n-butyltin analogue of carboplatin

Figure 22.2 Carboplatin and the di-n-butyltin analogue of carboplatin

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