Alemtuzumab

the peripheral blood and marrow of patients (10). In some studies, alemtuzumab-induced apoptosis has been reported to be caspase-independent (34).

Alemtuzumab has shown impressive results in refractory or relapsed CLL as well as up-front therapy for untreated CLL (35). The use of alemtuzumab to eradicate minimal residual disease of CLL is also reasonable (36). The role of Fc^ receptor polymorphisms on the clinical activity of alemtuzumab for CLL has not been extensively studies and will be discussed later.

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