Challenge of Studying Anticancer Agents

There are a number of limitations specific to the study of the pharmacogenetics of anticancer agents. Anticancer agents affect tumor and non-tumor cells. They have a narrow therapeutic index and a wide toxicity profile with the extreme end of the spectrum resulting in death. Thus, it is particularly important to identify genetic polymorphisms associated with toxicities related to these medications. Identifying heritable polymorphisms associated with chemotherapy cannot be performed in related, healthy individuals, thus forcing researchers to consider alternatives to current approaches.

Until recently, only a few studies have utilized human lymphocytes or Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines (LCLs) derived from the CEPH to identify heritable traits related to drug sensitivity or other drug-induced pharmacodynamic parameters (3,4). However, these studies are providing evidence for the broad applicability of this approach to pharmacogenomic research.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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