Egfr Function

The emergence of resistance to gefitinib and erlotinib in patients who were initially sensitive to the drug has dealt a large blow to target-based drug discovery efforts. In addition, the narrow pharmacogenomic profile of responders to EFGR-targeted therapy leaves a vast majority of patients with advanced NSCLC in the lurch. Tumors from this population that display primary resistance to gefitinib and erlotinib are likely to be genetically diverse and not dependent on EGFR function for growth and viability. As a corollary, these tumors may display addiction to other oncogenic proteins, possibly kinases, which might lead to the development of novel classes of kinase inhibitors that are specifically efficacious in subpopulations of NSCLC patients.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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