Methotrexate Mechanism Of Action

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Methotrexate inhibits folate metabolism by preventing methylenetetrahydrofolate reductase from converting 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate thus inhibiting thymidylate synthase conversion of dUMP to dTMP. DNA replication is effectively decreased by the diminution of dTMP availability. As shown in Fig. 2, multiple enzymes mediate the folate cycle. Thus, genetic variation in these enzymes may

Mechanism Action Anticancer Drugs

Fig. 1. Genetic factors impacting chemotherapy efficacy and toxicity.

ABC Trans porters

Fig. 1. Genetic factors impacting chemotherapy efficacy and toxicity.

Folate Mechanism And Growth
Fig. 2. Folic acid cycle and methotrexate.

modify the clinical impact of methotrexate therapy. The peer-reviewed studies describing the impact of these genetic variants are summarized below.

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