Other Monoclonal Antibodies In The Treatment

Campath-1 H (alemtuzumab, Campath® or MabCAMPATH®) is another monoclonal antibody targeting the CD52 antigen on tumor cells. It is a recombinant monoclonal antibody of the IgG1 isotype generated by cloning the hypervariable regions of the parent murine Campath-1 G into the framework regions of normal human IgG1.

The CD52 antigen, a 21- to 28-kDa glycopeptide, is expressed at high density on the surface of B- and T-lymphocytes, macrophages, and monocytes, but not hematopoietic stem cells (33). It is also expressed on all CLL cells and indolent B-cell lymphoma cells. The entire structure of the CD52 molecule has been determined. However, its function still remains to be revealed.

Although the precise mechanism of alemtuzumab activity is still under investigation, alemtuzumab exerts its therapeutic effects through binding to the CD52 antigen on target cells. CDC and ADCC occur by the activation of NK cells and macrophages through their Fc^ receptors with subsequent clearance of malignant lymphocytes from

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