Proteomics for Autoantibodies in Serum from Cancer Patients

Fujita et al. identified auto-antibodies reacting to peroxiredoxin VI in the sera of esophageal cancer patients (37). Hong et al. identified auto-antibodies reacting to cal-reticulin isoforms in the sera of pancreatic cancer patients (38). Le Naour et al. identified auto-antibodies reacting to Crt 32 in the sera of pancreatic cancer patients (39).

The final goal of clinical cancer proteomics is to discover biomarkers for early small cancers, to clarify pathogenesis and carcinogenesis of cancers, and to tailor the therapy for the cancer patients. Although a huge number of reports about the discovery of biomarkers by proteomics has been published, still no biomarker is being used practically in hospitals. However, some kinds of proteins detected in sera from cancer patients are expectable as abiomarker (24,37,38,39).

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