Proteomics for HCC Tissues from Patients

The differential expression of paired cancerous and non-cancerous tissues was visually compared; 12 up-regulated and 11 down-regulated spots were identified. The up-regulated proteins were identified as GRP75, GRP78, HSC71, HSP70.1, HSP60, glu-tamine synthetase (GS), triosephosphate isomerase (TIM), ATP synthetase beta chain, and alpha-enolase. The three protein spots of Mr 42,000 and pi 6.4-6.8 were identified as GS. The down-regulated proteins were identified as aldolase, arginase 1, enoyl-CoA hy-dratase, ketohexokinase, smoothelin, tropomyosin beta chain, ferritin light chain, serum albumin (18,19,20,21).

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