Summary

MicroRNAs are endogenous short non-coding RNAs that regulate gene expression mainly at the post-transcriptional level by base pairing to the 3' untranslated region of target messenger RNAs. At present, hundreds of microRNAs have been identified in humans, and some of them have been revealed to play a critical role especially in the initiation, progression, and malignant potential of various cancers. In this chapter, we discuss the role of microRNAs in cancer and its potential application for cancer therapy.

Key Words: MicroRNA; non-coding RNA; translational suppression; cancer; oncogene; tumor suppressor gene; diagnosis; antisense oligonucleotide; drug discovery

From: Cancer Drug Discovery and Development: Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response Edited by: F. Innocenti, DOI: 10.1007/978-1-60327-088-5_4, © Humana Press, Totowa, NJ

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