Vvu

A-443654, 279

AAG113-161, 38

AAL-993, 267

Abarelix, 84

ABC transporters, 388

Abelson kinase (see BCR-ABL kinase)

Abiraterone acetate, 77

ABJ879, 241

ABT-510, 318

ABT-518,315

ABT-751, 236

ABX-EGF, 264

Aclarubicin (aclacinomycin A), 110, 212, 215, 219 Aconitase, 105

Acridines, as intercalating agents, 206

Actinomycin D (dactinomycin), 114-115, 204

"Activated" bleomycin, 118

Acute promyelocytic leukemia (APL), 87

Acyclic retinoid, 420

Adapalene, 89, 420

Adaphostin, 274

Adenosine deaminase inhibitors, 42 ADEPT, 352,355, 364-367,377 Adiol, 74

ADI-PEG, 20 (see PEG-recombinant arginine deiminase) Adozelesin, 194 ADR-925, 106 Adrenocortical cancer, 85 Adriamycin, (see doxorubicin) AEW-541, 265 Aflatoxin B1, 426 AG-014699, 409 AG-2037, 38 AGT inhibitors, 279, 403 AKT, 279-280

inhibitors, 279 Alemtuzumab, 343 Alimta, (see pemetrexed) Alitretinoin, 87 Allopurinol, 42

Altratamine, (see hexamethylmelamine) Alvespimycin, 301 Alvocidib (flavopiridol), 253, 276 Ametantrone, 112

Aminoglutethimide, 72 5-aminolevulinic acid (ALA), 133 Aminopterin (AM), 33 deaza analogues, 36 Amonafide, 205 Amsacrine (mAMSA), 213 Anamycin, 112 Anaplastic astrocytoma, 166 Anastrazole, 72

1,4-Androstadiene-3,17-dione, 70 Angiogenesis, 265, 269, 279,312,316

endogenous inhibitors, 318-319 Angiostatin, 318 Angiozyme, 269

Anthracyclines, 102, 178, 200, 206, 214-216, 219, 365, 370, 373, 389, 398 cardiac toxicity, 104-105 effects on iron regulation, 105-107 formaldehyde DNA adducts, 108-110 Anthramycin, 196 Antiandrogens, 76, 80

Antiangiogenic agents, 312, 318-322, 328, 332 Antibody-directed enzyme prodrug therapy (see ADEPT) Antiestrogens, 58 non-steroidal, 58-62 steroidal, 62-65 Antifolate drugs, 28, 31-41 Anti-inflammatory agents, in cancer chemoprevention, 421-425 Antimetabolite enzymes, 50 Antimetabolites, definition, 10 Antimycin A, 298

Antioxidants, in cancer chemoprevention,

421-422, 425 Antisense oligonucleotide, 257, 285, 288, 295, 297,

298, 319, 340-343 AP-23573, 281 AP-5280, 372 AP-5346,372 APE-l inhibitors, 407 Apicidin, 335 APO2L (see TRAIL)

Apoptosis, 10, 23, 33, 103, 213, 232, 265, 279, 296, 299,308-311,318,320,322-324,332,346,355, 398, 400, 428 AQ4N, 355

Ara-C (see cytarabine) non-steroidal, 72-73 steroidal, 68-72 Aromatase inhibitors, 65 nonsteroidal, 72-73 steroidal, 68-72 Aromatase mechanism of action, 66-68 ARRY-142886 (AZD-6244), 295 Arzoxifene, 419 AS-1404, 246 Ascorbic Acid, 423 l-Asparaginase, 50 Aspartate transcarbamoylase, 11 Asulacrine, 214 ATM kinase, 411

ATP analogues (ATP mimics), 253, 258, 262-263,

267-283, 295, 301 ATP-binding cassette efflux pumps, 388

inhibitors, 388-397 Aureolic acid, 337 Auristatin PE, 234 Aurora kinase inhibitors, 283-284 AVE8062A, 245 Axitinib (AG-013736), 268 5-Azacytidine, 325 Azacitidine, 48 Azaserine, 39 Azathioprine (imuran), 42 AZD-0530, 274 AZD-1152, 283 AZD-2171, 268 AZD-3409, 291 Azinomycins, 158 Aziridine alkaloids, 182-189 Aziridines (ethyleneimines), 154-158 Aziridinylquinones, 155-157, 357 AZQ (see diaziquone)

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