Anticancer Drugs Acting via Radical Species Photosensitizers and Photodynamic Therapy of Cancer

Contents 1. Introduction: Radicals and Other Reactive Oxygen Species 93

2. Biological Effects of ROS 95

2.1. Membrane phospholipid peroxidation 95

2.2. Malondialdehyde generation and its consequences 96

2.3. DNA strand cleavage 98

2.4. Oxidation of DNA bases 100

2.5. Formaldehyde generation 102

2.6. ROS as signaling molecules 102

3. Anthracyclines and Their Analogs 102

4. Mitoxantrone and Related Quinones 112

5. Actinomycin D 114

6. Chartreusin, Elsamicin A, and Related Compounds 116

7. Bleomycins 116

8. Enediyne Antibiotics 122

9. Tirapazamine 126

10. Penclomedine 128

11. Radiosensitizers 129

12. Photodynamic Therapy of Cancer 132 References 135

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