Anticancer Drugs That Inhibit Hormone Action

Contents 1. Introduction 54

2. Estrogens and Their Involvement in Carcinogenesis 54

3. Antiestrogens as Antitumor Drugs 58

3.1. Nonsteroidal antiestrogens (SERMs) 58

3.2. Steroidal antiestrogens 62

4. Aromatase Inhibitors 65

4.1. Aromatase mechanism of action 67

4.2. Steroidal aromatase inhibitors (type I inhibitors) 68

4.3. Nonsteroidal aromatase inhibitors (type II) 72

5. Steroid Sulfatase Inhibitors 73

6. Androgen-Related Antitumor Agents 75

6.1. Antiandrogens 76

6.2. Inhibitors of 14a-demethylase and 17a-hydroxylase 77

6.3. Inhibitors of 5a-reductase 77

7. Regulation of Steroidal Hormone Synthesis as a Target for Antitumor Drugs 79

7.1. Introduction 79

7.2. GnRH (LHRH) agonists 81

7.3. GnRH (LHRH) antagonists 82

8. Miscellaneous Steroid Hormone-Related Anticancer Therapy 85

8.1. Gestagens as antitumor agents 85

8.2. Glucocorticoids and inhibitors of their biosynthesis as antitumor agents 85

9. Compounds Acting on Other Proteins of the Nuclear Receptor Superfamily: Retinoids 86

References 90

Medicinal Chemistry of Anticancer Drugs © 2008 Elsevier B. V.

DOI: 10.1016/B978-0-444-52824-7.00003-2 All rights reserved.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment