As mentioned in Section 3 of Chapter 4, this class of drugs were introduced as chelating agents, since they behave as pro-drugs to EDTA amides, and are useful as cardioprotectors when associated with anthracyclines. They have subsequently been shown to inhibit topoisomerase II at a point upstream to the formation of the cleavable DNA-enzyme complex by stabilizing the closed-clamp form of topoisomerase II as a post-passage complex. This is achieved by inhibiting the ATPase activity of the enzyme after interaction with its N-terminal domain. The main bis(dioxopiperazines)79 are shown below.


10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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