Cancer

Generation of^^ DNA alkylation E2-3,4-quinone and depurination

FIGURE 3.13 Pathways involved in tumorogenesis by estrogens.

FIGURE 3.13 Pathways involved in tumorogenesis by estrogens.

Androstenedione

Androstenedione

Estrone

Estrone

Testosterone

Estradiol

FIGURE 3.14 Biotransformations catalyzed by aromatase.

Testosterone

Estradiol

FIGURE 3.14 Biotransformations catalyzed by aromatase.

with bisphosphonates to compensate for their pro-osteoporotic effects has still not been fully evaluated, and other possible long-term effects remain unknown.21

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