D

DACA (XR5000), 214 Dacarbazine (DTIC), 165 Dactinomycin (see actinomycin D) Dasatinib (BMS-354825), 274 DAUF, 108

Daunorubicin (daunomycin), 102, 107, 390

DaunoXome, 383

Death receptors, 298-299

Decitabine, 325

Deltanoids, 420

14a-Demethylase inhibitors, 77 Deoxyepothilone B, 241 Detirelix, 83 Dexamethasone, 321 Dexaminoglutethimide, 72 Dexrazoxane (ICRF-159), 106 Dexverapamil, 392 dFdC (see gemcitabine) DHFR (see dihydrofolate reductase) Diaziquone (AZQ), 155, 357 Dibenzophenanthrolines, 339 Didox, 14 Diflomotecan, 221

Dihydrofolate reductase (DHFR), 19-22, 28

inhibitors, 32-38 Dihydroorotate dehydrogenase, 11 5,6-Dihydro-5-azacytidine (DHAC), 325-326 Dihydropyrimidine dehydrogenase (DPD), 27

5,6-Dimethylxanthenone acetic acid, 246

Discodermolide, 244

Distal activation, 152

Distamycin A, 178-182, 194

Ditercalinium, 207

DMXAA, 246

DNA biosynthesis, summary, 10 DNA crosslinking, 140-141 by aziridines, 155-156 by epoxides, 158-159 by methanesulfonates, 159-160 by mitomycin C, 183-185 by mitosenes, 186-187 by nitrogen mustards, 144-146 by nitrosoureas, 163-164 DNA glycosylase, 402

inhibitors, 404-408 DNA intercalation, 200-201 DNA methyltransferases (DNMTs), 323 inhibitors, 323-330

DNA microarrays, 6 DNA oxopropenylation, 98 DNA-PK, 402, 411-412 DNA-repair pathways, 340, 402

chemosensitizers acting on, 401-412 in double-strand DNA breaks, 411 inhibitors, 340 DNA repair system inhibitors, 340 DNA strand cleavage (scission), by oxidative stress, 98-99,112,118-121, 127-128

following DNA alkylation, 144-145 mediated by topoisomerases, 203,209-213,218, 221, 223-225 DNA topoisomerases (see topoisomerases) Docetaxel, 238 Dofequidar, 393 Dolastatin 10, 233

DON (6-diazo-5-oxo-l-norleucine), 39, 369 DOXF, 108

DOX-GA3, 365, Doxifluridine, 24 Doxil (see PEGylated liposomal doxorubicin) Doxorubicin (adriamycin), 102-103, 107, 372-373,390 HPMA polymer conjugates, 371-373, 377-378 liposome formulations, 380-383 neuropeptide conjugate, 374 prodrug in ADEPT strategy, 365-366 Droloxifene, 59 DT-diaphorase (DTD), 155 Duocarmycins, 194 Dutasteride, 79 Dynemicin A, 122, 125

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