DNA Alkylating Agents

Contents 1. Introduction 139

2. Nitrogen Mustards 141

2.1. Introduction 141

2.2. DNA alkylation by nitrogen mustards and cytotoxicity mechanisms 142

2.3. Structure-activity relationships in nitrogen mustards 144

2.4. Site-directed nitrogen mustards 147

3. Aziridines (Ethyleneimines) 154

4. Epoxides 158

5. Methanesulfonates 159

6. Nitrosoureas 160

7. Triazenes 165

8. Methylhydrazines 166

9. 1,3,5-Triazines: Hexamethylmelamine and Trimelamol 168

10. Platinum Complexes 169

11. Miscellaneous Alkylating and Acylating Antitumor Agents 173 References 174

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