The last four compounds can be considered as active site-directed irreversible inhibitors, since they contain a 4-anilinoquinazoline structural fragment that can be recognized by the ATP site and also an electrophilic a,p-unsaturated carbonyl moiety, responsible for covalent binding to the enzyme. The conserved cysteine residue Cys-773 within the ATP binding pocket seems to be responsible for the nucleophilic attack to this Michael substrate18 (Fig. 9.9).

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

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