H h3c ch3 ch3 ch3

Acyclic retinoid (polyprenoic acid)

co2h vCH

4-Hydroxyphenylretinamide (fenretinide)

H3CO

Acyclic retinoid (polyprenoic acid)

H3CO

Adapalene

CO2H

Adapalene

Bexarotene is selective for RXRs (rexinoid) and has been approved by the FDA for cutaneous T-cell lymphoma.59 In combination with chemotherapeutic agents, such as cisplatin and vinorelbine, bexarotene has demonstrated encouraging results in patients with advanced non-small cell lung cancer, and two Phase III trials are currently under way to fully characterize its role in the treatment of this disease.60

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