Pzm

Haber-Weiss reaction, 94 Halichondrin B, 5-6, 233 "Hard" electrophiles, 140 HATs, 331

HDAC, inhibitors, 323 inhibitors, 330-336 Heat-shock proteins (see HSPs) Hemiasterlin, 234 Heparan sulfate (HS), 316 Heparanase inhibitors, 316 Hepsulfam, 159 HER-1 (see EFGR) HER-2, 258, 261, 263

inhibitors, 264 Herpes simplex virus thymidine kinase, 345 Hexamethylmelamine

(HMM, altretamine), 167 Histone acetylation, 331 Histone deacetylases (see HDAC) Histone methylation, 337 Histones, 330 HKI-272, 263

HMPA copolymer-camptothecin, 371 HMPA copolymer-paclitaxel, 371

Hoechst 33258 (see pibenzimol) Homocamptothecins, 221 HR22C16 (see monastroline) HSPs (heat-shock proteins), 297, 300

inhibitors, 300-301 HTI-284, 234 Hydralazine, 329 Hydroxamic acid, 313 Hydroxyl radical, 94-96,100-105, 116,118,

127-129, 421, 424-425 17a-Hydroxylase inhibitors, 77 4-Hydroxyestradiol (4-OHE2), 56 Hydroxyurea, 13

Hypoxia-based strategies for tumor-specific prodrug activation, 354-362 Hypoxia-inducible factor 1 (HIF-1), 207 Hypoxic-selective nitrogen mustards, 361

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