reductases through the standard mechanism, involving the formation of 6.23 and subsequent DNA alkylation by a mechanism related to that proposed for the case of mitomycin. On the other hand, in vitro studies have shown that 6.22 exists predominantly as its spiro isomer 6.24; this intermediate is proposed to react with intracellular thiols to give 6.25, thus providing an alternative route for hydroqui-none generation that is not dependent on reductase activity.44 Due to this mechanism, KW-2149 is active in non-hypoxic tumor cells and in cell lines that express low levels DT-diaphorase and are therefore resistant to mitomycin.45

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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