Hcl Oh

Elsamicin A

H2NX^rCH3 h3co1

These compounds cause single-strand scission of DNA in the presence of reducing agents via the formation of free radicals. ESR spin-trapping experiments showed that the elsamicin A-iron complex produces hydroxyl radicals in the presence of dithiothreitol as reducing agent.67 The most probable mechanism involves reduction of either carbonyl group followed by reoxidation by oxygen (Fig. 4.24).

Because elsamicin A is an extremely potent inhibitor of topoisomerase II, these compounds will be further discussed in Chapter 7.

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