Info

N-Arg364-

DNA NH2

FIGURE 7.16 Key interactions in the topotecan-DNA-topo I complez.

Camptothecin bound to the Fre0 campt0thecin topo-DNA complex

FIGURE 7.17 Unfavourable activation entropy for the dissociation of the camptothecin ternary complex.

Camptothecin bound to the Fre0 campt0thecin topo-DNA complex

FIGURE 7.17 Unfavourable activation entropy for the dissociation of the camptothecin ternary complex.

In this model, the very high activation entropy associated with the reversal process is due to the need for the CPT derivative to accumulate an ordered layer of water molecules around itself, as shown in Fig. 7.17 for the case of CPT.100

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment