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From the triplet state

FIGURE 4.48 DNA adducts with 8-methoxypsoralen.

other types of cancer, such as cervical cancer, esophageal, early stage central type

lung cancer, and head and neck cancers, among other applications.

Psoralens have been traditionally employed for skin diseases, including psoriasis, but the only member of the group approved for cancer treatment is 8-methoxypsoralen (8-MOP, methoxsalen, Uvadex), which is used in the treatment of cutaneous T cell lymphoma. This compound is administered orally and then some blood is withdrawn, the aberrant white cells are separated and irradiated and then recombined with the other blood constituents and reinjected.109 In this process, after weakly intercalating into DNA, irradiation of 8-MOP promotes the formation of [2 + 2] cycloadducts between its 3-4 and 5-6 double bonds and the 5-6 double bonds of adjacent thymidine bases of DNA (Fig. 4.48). Both possible monoadducts and bisadducts 4.71 have been isolated, the formation of the latter leading to DNA cross-links.110

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