the indole nitrogen leads to a low acidity for 5.29. For instance, the pKa of the semiquinone derived from EO9 is 9.3, while the corresponding pKa values of benzosemiquinones are below neutrality. For this reason, benzosemiquinones are mostly deprotonated and the hydrogen sigmatropic shift cannot take place.36 Several natural products, including the mitomycins, FR-900482, and FR-69979, among others, contain one fused aziridine ring37 but, because of their specificity toward the minor groove, these agents will be studied in Chapter 6.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

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