Info

CH3 CH3

Actinomycin D

CH3 CH3

Actinomycin D

The ability of actinomycin D to generate superoxide radicals was first reported in 1978,65 and is probably due to the mechanism summarized in Fig. 4.23. However, the clinical relevance of this mechanism is very doubtful, since the concentration required to generate free radicals is approximately 10 ~4 M, whereas actinomycin concentrations as low as are sufficient to inhibit RNA tran-

scription.66 For further discussion of the antitumor activity of the actinomycins associated to DNA intercalation, see Chapter 7.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment