Inhibitors of the binding of topoisomerase II to DNA Aclarubicin

Although most anthracyclines act as specific topoisomerase II poisons, some of them, such as aclarubicin (aclacinomycin A), can act by different mechanisms. This drug is clinically used in the treatment of acute myelocytic leukaemia and it behaves as a strong intercalating agent that prevents the binding of topoisomerase II to DNA and hence as a topoisomerase II catalytic inhibitor. Subsequent studies have shown that aclarubicin is also a topoisomerase I inhibitor at biologically relevant concentrations.77

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