Inhibitors of the binding of topoisomerase II to DNA Aclarubicin

Although most anthracyclines act as specific topoisomerase II poisons, some of them, such as aclarubicin (aclacinomycin A), can act by different mechanisms. This drug is clinically used in the treatment of acute myelocytic leukaemia and it behaves as a strong intercalating agent that prevents the binding of topoisomerase II to DNA and hence as a topoisomerase II catalytic inhibitor. Subsequent studies have shown that aclarubicin is also a topoisomerase I inhibitor at biologically relevant concentrations.77

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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