FIGURE 10.8 A. Recognition sequence of heparan sulfate. B. Mechanism of the reaction catalyzed by heparanase.

with reduced molecular sizes, and one of these compounds, the phosphosulfo-mannan PI-88, is in clinical trials in several cancers.24 PI-88 is a mixture of chemically sulfated oligosaccharides, ranging from di- to hexasaccharides and with the majority (60%) being pentasaccharides. Besides being a heparanase inhibitor, PI-88 also inhibits angiogenesis by antagonizing the interactions of proangiogenic growth factors (e.g., VEGF and bFGF) and their receptors with HS.


10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

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