Merbarone

Merbarone is a derivative of thiobarbituric acid that was discovered in the course of a study of a large number of barbituric acid analogues by the NCI. This compound has been shown to inhibit the induction of DNA-topoisomerase II cleavable complexes and has been tested clinically against a large number of tumors,78 although it showed nephrotoxicity and poor anticancer activity.

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