Methanesulfonates

Methanesulfonate is a good leaving group because of the efficient delocalization of negative charge between three oxygen atoms. For this reason, several compounds containing two methanesulfonate groups separated by a polymethylene chain were tested as antitumor agents, finding that the optimal activity corresponded to the compound with four carbon atoms (busulfan). Other members of this family are piposulfan, improsulfan, hepsulfam, and the previously mentioned diepoxide prodrug treosulfan.

Busulfan is used in the treatment of chronic granulocytic leukemia and, in high-dose combination with cyclophosphamide, to condition patients for alloge-neic bone marrow transplantation. It is particularly toxic for pulmonary tissue, and this toxicity may be dose-limiting.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment