Methylhydrazines

When a series of N,N'-dialkylhydrazine derivatives that had been prepared as monoaminooxidase (MAO) inhibitors were routinely submitted to cytotoxicity tests, it was shown that compounds with an N-methyl substituent had anticancer potential. This discovery ultimately led to the development of procarbazine, which was approved for use in combination therapy for advanced Hodgkin's disease. Mechanistically, procarbazine is a unique agent with multiple sites of action that is not cross-resistant with other alkylating agents. It inhibits nh-nh-ch3

Procarbazine

R-CH2-N^NH-CH3 O2

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