When a series of N,N'-dialkylhydrazine derivatives that had been prepared as monoaminooxidase (MAO) inhibitors were routinely submitted to cytotoxicity tests, it was shown that compounds with an N-methyl substituent had anticancer potential. This discovery ultimately led to the development of procarbazine, which was approved for use in combination therapy for advanced Hodgkin's disease. Mechanistically, procarbazine is a unique agent with multiple sites of action that is not cross-resistant with other alkylating agents. It inhibits nh-nh-ch3



10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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