N

Another compound that has been reported to be moderately selective against Aurora A is PHA-739358, which is in Phase I clinical studies. The structure or pharmacological profile of PHA-739358 has not been divulged, but it could be related to other Aurora analogues derived from the tetrahydropyrrolo[3,4-c] pyrazole framework reported by the same company as an adenine mimetic in the ATP site of Aurore kinases (Fig. 9.22).90

HN R3

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