AAL-993 (ZK-260255)

The crystal structure of the drug-protein complex showed that, similar to imatinib, AAL-993 targets the inactive conformation of the enzyme. The binding involves three hydrogen bond interactions (Fig. 9.12) and several hydrophobic interactions. Thus, the phenyl ring of the anthranilamide unit is sandwiched between the hydrophobic side chains of Val-916 and Lys-868, and the trifluoro-methylphenyl substituent fits a lipophilic pocket.26

Vandetanib (ZD6474) belongs to the quinazoline family and is being evaluated in several Phase II clinical trials. Quinazolines were initially developed as EGFR-TK

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment