N

DNA poiymerase Base Base j inhibition

R = H, OH Other mechanisms

FIGURE 2.43 Antitumor mechanisms of ribonucleoside triphosphates.

polymerase, and other mechanisms (e.g., inhibition of RNR or PNP) are known for particular compounds (Fig. 2.43). A general problem associated with these drugs is due to their cytotoxicity to lymphoid cells, resulting in significant and long-lasting immunosuppression.

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