The butyric acid moiety modulates not only the aqueous solubility and reactivity as alkylating agents of the nitrogen mustards, but also their metabolism. Thus, a significant fraction of chlorambucil is metabolically degraded to an active phenylacetic acid mustard via p-hydroxylation following the biochemical pathway employed for fatty acid degradation. In the case of bendamustin, the active hydroxy metabolite is more stable and is apparently not transformed into the acetic acid analog.8

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