Nonsteroidal aromatase inhibitors type II

This group of inhibitors comprises structurally varied compounds that are able to bind to the active site of aromatase through the coordination of an heterocyclic nitrogen atom, usually an imidazole or triazole ring, to the iron atom of the heme group of the enzyme. Because of the similarity of aromatase with other essential enzymes of the cytochrome P450 group, the main problem to be solved is one of selectivity. On the contrary, they have the advantage over steroidal inhibitors of not being subject to metabolism by the cytochrome enzyme system. The structures of the main drugs belonging to this group are given below.

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