FIGURE 6.17 Reversibility of the covalent DNA-ET-743 complex.

Because of the complexity of the ET-743 structure, extensive studies have been carried out on the preparation of simpler analogues. Among them, the most important is phthalascidin,74 with an activity similar to that of the natural product, where the phthalimino group plays a similar role to the spirotetrahydroisoquino-line unit in ET-743.75 Another related compound is PM00104/50, which has recently begun Phase I clinical trials for the treatment of solid tumors.76

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment