Most known proteasome inhibitors4,5 are peptidomimetics containing an electrophilic functional group, and can therefore be classified as site-directed enzyme inhibitors. This group is normally placed at one end of the molecule and reacts with the threonine hydroxyl after its activation. Many of these compounds bear a close relationship with inhibitors of serine proteases (e.g., HIV protease). Some representative examples are given below. Among these compounds, borte-zomib was approved in 2003 for the treatment of multiple myeloma, the second most common hematological cancer, and is currently being clinically evaluated for various other malignancies.6 Bortezomib (PS-341, LDP-341, MLN-341) affects multiple signaling cascades (e.g., NF-kB) within the cell because of proteasome inhibition and induces G2/M phase arrest followed by apoptosis in cancer cells.7

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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