In contrast with nitrogen mustards, where the rate-limiting step is the unim-olecular formation of the aziridinium ion, busulfan reacts with guanine N-7 by an SN2 mechanism (Fig. 5.23), where the rate-limiting step depends on the concentration of both reaction partners.42 The formation of interstrand DNA cross-links has been demonstrated for busulfan43 and treosulfan.44

The study of metabolites of busulfan suggests that it is also able to alkylate cysteine residues. Thus, the urinary excretion of compound 5.32 can be explained by the mechanism summarized in Fig. 5.24 and involves a double nucleophilic attack by cysteine.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment